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With the rapid expansion of urban built-up areas in recent years, it has become particularly urgent to develop a fast, accurate and popularized urban built-up area extraction method system. As the direct carrier of urban regional relationship, urban built-up area is an important reference to judge the level of urban development. The accurate extraction of urban built-up area plays an important role in formulating scientific planning thus to promote the healthy development of both urban area and rural area. Although nighttime light (NTL) data are used to extract urban built-up areas in previous studies, there are certain shortcomings in using NTL data to extract urban built-up areas. On the other hand, point of interest (POI) data and population migration data represent different attributes in urban space, which can both assist in modifying the deficiencies of NTL data from both static and dynamic spatial elements, respectively, so as to improve the extraction accuracy of urban built-up areas. Therefore, this study attempts to propose a feasible method to modify NTL data by fusing Baidu migration (BM) data and POI data thus accurately extracting urban built-up areas in Guangzhou. More accurate urban built-up areas are extracted using the method of U-net deep learning network. The maximum built-up area extracted from the study is 1103.45 km2, accounting for 95.21% of the total built-up area, and the recall rate is 0.8905, the precision rate is 0.8121, and the F1 score is 0.8321. The results of using POI data and BM data to modify NTL data to extract built-up areas have not been significantly improved due to the fact that the more data get fused, the more noise there would be, which would ultimately affect the results. This study analyzes the feasibility and insufficiency of using big data to modify NTL data through data fusion and feature extraction system, which has important theoretical and practical significance for future studies on urban built-up areas and urban development.