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The use of sensors in the real world is on the rise, providing information on medical diagnostics for healthcare and improving quality of life. Optical fiber sensors, as a result of their unique properties (small dimensions, capability of multiplexing, chemical inertness, and immunity to electromagnetic fields) have found wide applications, ranging from structural health monitoring to biomedical and point-of-care instrumentation. Furthermore, these sensors usually have good linearity, rapid response for real-time monitoring, and high sensitivity to external perturbations. Optical fiber sensors, thus, present several features that make them extremely attractive for a wide variety of applications, especially biomedical applications. This paper reviews achievements in the area of temperature optical fiber sensors, different configurations of the sensors reported over the last five years, and application of this technology in biomedical applications.