Unicorn horn, Harry Potter Wiki

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The horn of a unicorn had magical properties that made it a useful ingredient in potions, such as the Antidote to Common Poisons. In classical myths, unicorn horns had purification properties which were used to dissolve poisons. This could be why it was used in the Antidote to Common Poisons. There was a lively Muggle trade in unicorn horn, which they believed to have medicinal properties. However, most of these supposed horns were fake, and the few real ones that did pass into Muggle possession