Genetic variants associated with breast size also influence breast cancer risk, BMC Medical Genetics
4.9 (303) In stock
![](https://media.springernature.com/m685/springer-static/image/art%3A10.1186%2F1471-2350-13-53/MediaObjects/12881_2011_Article_970_Fig2_HTML.jpg)
Background While some factors of breast morphology, such as density, are directly implicated in breast cancer, the relationship between breast size and cancer is less clear. Breast size is moderately heritable, yet the genetic variants leading to differences in breast size have not been identified. Methods To investigate the genetic factors underlying breast size, we conducted a genome-wide association study (GWAS) of self-reported bra cup size, controlling for age, genetic ancestry, breast surgeries, pregnancy history and bra band size, in a cohort of 16,175 women of European ancestry. Results We identified seven single-nucleotide polymorphisms (SNPs) significantly associated with breast size (p<5·10−8): rs7816345 near ZNF703, rs4849887 and (independently) rs17625845 flanking INHBB, rs12173570 near ESR1, rs7089814 in ZNF365, rs12371778 near PTHLH, and rs62314947 near AREG. Two of these seven SNPs are in linkage disequilibrium (LD) with SNPs associated with breast cancer (those near ESR1 and PTHLH), and a third (ZNF365) is near, but not in LD with, a breast cancer SNP. The other three loci (ZNF703, INHBB, and AREG) have strong links to breast cancer, estrogen regulation, and breast development. Conclusions These results provide insight into the genetic factors underlying normal breast development and show that some of these factors are shared with breast cancer. While these results do not directly support any possible epidemiological relationships between breast size and cancer, this study may contribute to a better understanding of the subtle interactions between breast morphology and breast cancer risk.
Why are breasts different sizes?
![](https://media.springernature.com/w215h120/springer-static/image/art%3A10.1007%2Fs10508-014-0304-4/MediaObjects/10508_2014_304_Fig1_HTML.gif)
Stereotypical and Actual Associations of Breast Size with Mating-Relevant Traits
![](https://bocahindonesia.com/wp-content/uploads/2022/03/apakah-payudara-kecil-mempengaruhi-kesuburan_.jpg)
Apakah Payudara Kecil Mempengaruhi Kesuburan?
![](https://imagepphcloud.thepaper.cn/pph/image/72/234/267.jpg)
智商随妈,性格随爸?你所不知道的遗传真相_澎湃号·湃客_澎湃新闻-The Paper
![](https://nci-media.cancer.gov/pdq/media/images/746226.jpg)
Genetics of Breast and Gynecologic Cancers (PDQ®) - NCI
![](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs10549-022-06560-0/MediaObjects/10549_2022_6560_Fig1_HTML.png)
Mutational spectrum of breast cancer susceptibility genes among women ascertained in a cancer risk clinic in Northeast Brazil
![](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fgim.2017.96/MediaObjects/41436_2018_Article_BFgim201796_Fig1_HTML.jpg)
Racial/ethnic differences in multiple-gene sequencing results for hereditary cancer risk
![](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41421-023-00614-3/MediaObjects/41421_2023_614_Fig1_HTML.png)
Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities
![](https://woman2womenblog.files.wordpress.com/2015/03/breast-cancer-woman-with-pink-ribbon-1336055074592_original.jpg)
BREAST CANCER RISK: 12 COMMON MISCONCEPTIONS AND CONTROVERSIES
Increase Breast Size Without Surgery? Chati Ka Size Kaise Badhaye - Dr. Ibrahim в 2024 г
Gene-Panel Sequencing and the Prediction of Breast-Cancer Risk
A Population-Based Study of Genes Previously Implicated in Breast
Increase Breast Size Without Surgery? Chati Ka Size Kaise Badhaye