Yunlong Richard Cao on X: It's critical to test how these RBD hotspots could combine to achieve max immune evasion without losing affinity to ACE2. After careful consideration, besides the emerging K478R/F456L

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Yunlong Cao Lab Peking University

The Potential for SARS-CoV-2 to Evade Both Natural and Vaccine-induced Immunity

Yunlong Richard Cao on X: Our paper on JN.1 is now online @TheLancetInfDis! The manuscript explains how a single RBD mutation L455S could turn BA.2.86 into a heavy immune evasive variant JN.1. Notably, JN.1 is now approaching worldwide

Yunlong Cao Lab Peking University

PDF) Underlying driving forces of the SARS-CoV-2 evolution: immune evasion and ACE2 binding affinity

Passive Immunotherapy Against SARS-CoV-2: From Plasma-Based Therapy to Single Potent Antibodies in the Race to Stay Ahead of the Variants

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The Potential for SARS-CoV-2 to Evade Both Natural and Vaccine-induced Immunity

Yunlong Richard Cao on X: Updates on BA.2.86. 1) BA.2.86's ACE2 binding affinity is very high. 2) BA.2.86 has lower fusogenicity than XBB.1.5. 3) BA.2.86's infectivity in Vero cells is similar to

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution

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Thread by @yunlong_cao on Thread Reader App – Thread Reader App