miR-410-3p suppresses breast cancer progression by targeting Snail
4.8 (756) In stock
miR-410-3p acts as an oncogene or tumor-suppressor gene in various types of cancer. However, its role in breast cancer remains unknown. In the present study, expression of miR-410-3p in 30 breast cancer and paired adjacent normal tissues was detected by RT-qPCR. The expression of miR-410-3p was downregulated in 76.7% of the breast cancer samples. To further validate the expression of miR-410-3p in breast cancer, we analyzed miR-410-3p expression profiling data set from The Cancer Genome Atlas (TCGA) including 683 breast cancer and 87 normal breast tissues. We observed that the expression of miR-410-3p was downregulated in breast cancer tissues. Next, we investigated the influence of miR-410-3p on cell proliferation by transiently transfecting the miR-410-3p mimic or inhibitor, as well as their corresponding controls in the MDA-MB-231 and MCF7 cell lines. miR-410-3p overexpression reduced cell growth, colony formation and the number of EdU-positive cells in the MDA-MB-231 cells. In contrast, inhibition of miR-410-3p in the MCF7 cells resulted in a higher proliferation rate as assessed by MTT assay, plate colony formation and EdU assays. Furthermore, miR-410-3p inhibited epithelial-mesenchymal transition. In addition, Snail was found to be a direct target of miR-410-3p based on a luciferase assay. Overexpression of Snail was able to rescue the effect of miR-410-3p in breast cancer cells. Moreover, miR‑410-3p was inversely expressed with Snail in breast cancer samples. Our data provide new knowledge regarding the role of miR-410-3p in breast cancer progression.
CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the
miR-410-3p regulates proliferation and apoptosis of fibroblast-like synoviocytes by targeting YY1 in rheumatoid arthritis - ScienceDirect
HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells
Full article: LINC00680 Promotes the Progression of Non-Small Cell Lung Cancer and Functions as a Sponge of miR-410-3p to Enhance HMGB1 Expression
LncRNA SNHG6 promotes breast cancer progression and epithelial
HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells
miR-410-3p regulates proliferation and apoptosis of fibroblast-like synoviocytes by targeting YY1 in rheumatoid arthritis - ScienceDirect
Full article: LINC00680 Promotes the Progression of Non-Small Cell
miR-410-3p is induced by vemurafenib via ER stress and contributes
Cripto-1 promoter activity in cells over expressing Snail. (A)
CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the
Fashion Hands-Free Breast Pump Bra Parturient Without Steel Ring
Bradford White 224-47776-15 Magnesium Anode 3 inch Nipple x 36 inch L
Gertrude, 20 Stripper © 36 miles away l\/Iy pussy always moist
- Poka Ropa e Vargense vão disputar o título do Amador Série B, no domingo – Gazeta Bragantina
- Buffbunny Collection INNERLIGHT
- Two cars drifting battle on race track with smoke, Aerial view two
- Sexy Nurse Jackie Sexy Doctor Stethoscope Cleavage Funny
- Fruit of the Loom Women's Seamless Pullover Bra With Built-in Cups Bra, -In The Buff, S at Women's Clothing store
- Type A Comfort Absorbent Folding Microfibre Dish Drying Mat & Draining Rack, Grey, 20 x 16-in